While Manchester City are runaway leaders in the title race, top four, European football and relegation are all up for grabs.
The action kicked off on Friday night as Newcastle stole a point from Aston Villa with a stoppage time equaliser. Saturday offers four games with Chelsea and Leeds early on, Crystal Palace hosting West Brom, Burnley at Everton and then leaders Man City at Fulham,
Sunday offers plenty of intrigue with Southampton and Brighton battling to avoid getting sucked into a relegation battle. Leicester then host basement side Sheffield United before a huge north London derby between Tottenham and Arsenal, while West Ham head to Manchester United to round off the action.
Last but not least, champions Liverpool are at Wolves on Monday night.
Premier League fixtures and results (GMT)
Newcastle 1-1 Aston Villa (8pm)
Leeds vs Chelsea (12:30pm)
Crystal Palace vs West Brom (3pm)
Everton vs Burnley (5:30pm)
Southampton vs Brighton (12pm)
Leicester vs Sheffield Utd (2pm)
Arsenal vs Tottenham (4:30pm)
Manchester United vs West Ham (7:15pm)
Wolves vs Liverpool (8pm)