Erik Lamela also adds a touch of chaos and work rate, and made a case for inclusion with a strong showing in the Europa League win over Dinamo Zagreb.
Dele Alli and Tanguy Ndombele could also play at 10, although the latter is likely to form a midfield two with Pierre-Emile Hojbjerg having been rested against Palace.
Elsewhere, Mourinho has said he has a decision to make at right-back, with Serge Aurier returning on Thursday after Matt Doherty played the last two games.
Toby Alderweireld and Sergio Reguilon are expected to return to the back four. Giovani Lo Celso remains the only casualty.
Tottenham predicted XI (4-2-3-1): Lloris; Aurier, Sanchez, Alderweireld, Reguilon; Hojbjerg, Ndombele; Bale, Lucas, Son; Kane.
Venue: Emirates Stadium, Sunday March 14, 16.30
Spurs squad from: Lloris, Hart, Whiteman, Aurier, Doherty, Tanganga, Rodon, Alderweireld, Dier, Sanchez, Davis, Reguilon, Hojbjerg, Winks, Sissoko, Ndombele, Dele, Bergwijn, Lamela, Lucas, Son, Vinicius, Bale, Kane.
Last meeting: Spurs 2-0 Arsenal (Son, Kane)