The UFC is set to host its first full-capacity event in 13 months, its president Dana White says.
UFC 261 has been scheduled for 24 April in Jacksonville, Florida.
The UFC would become the first American sports organisation to host a full crowd since the start of the coronavirus pandemic.
The event will feature three title fights, headlined by a rematch between welterweight champion Kamaru Usman and Jorge Masvidal.
Women’s flyweight champion Valentina Shevchenko takes on Jessica Andrade, while strawweight champion Zhang Weili faces Rose Namajunas.
The event will be staged at the VyStar Veterans Memorial Arena, which holds 15,000 people.
Lenny Curry, mayor of Jacksonville, tweeted: “Dana White, governor Ron DeSantis and I will continue to demonstrate that Florida is poised to safely host signature sporting events watched globally. Welcome back to Jacksonville UFC. Let’s go.”
The first match-up between Usman and Masvidal was one of the biggest fights of 2020 as the UFC staged events behind closed doors on Abu Dhabi’s Yas Island, which was dubbed Fight Island.
Usman claimed a unanimous decision win over Masvidal last July before making a third defence of his title against Gilbert Burns last month.
Britain’s Leon Edwards hoped to secure a title shot against Usman before his fight with Belal Muhammad last weekend was declared a no contest following an accidental eye poke.